All aquatic life for fifty miles was dead or mutated. No wonder little Louis took an interest in purifying beer and milk, two products which had an excellent record for making people sick. Today, of course, every damn thing is sanitized. When you visit Dole and think how pretty the Rue des Tanneries is, remember your memory of the worst smell you’ve ever encountered and apply it in front of Louis Pasteur’s childhood home. You may never wear leather or drink milk or beer ever again.